1. In the case of hemolytic anemia , PGK deficiency occurs in the erythrocytes. 2. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia . 3. The most common clinical manifestations are neonatal jaundice and acute hemolytic anemia . 4. It has not been associated with autoimmune hemolytic anemia of the fetus. 5. This includes : aplastic, posthemorrhagic, and hemolytic anemias and anemia of chronic disease. 6. In general, hemolytic anemia occurs as a modification of the RBC life cycle. 7. Aldolase A deficiency has been associated with myopathy and hemolytic anemia . 8. Individuals with cold agglutinin disease present with signs and symptoms of hemolytic anemia . 9. In autoimmune hemolytic anemia , concentrations of hemoglobin A1 ( HbA1 ) is undetectable. 10. Fortunately, apart from these episodes of hemolytic anemia , most G6PD-deficient individuals are entirely asymptomatic.
