1. When glucose is transported into the cell it is phosphorylated by hexokinase . 2. By blocking the enzyme hexokinase , it prevents glucose phosphorylation. 3. A hydropathy analysis of hexokinase in yeast has been created by these standards. 4. Therefore, hexokinase is most likely not an integral membrane protein in yeast. 5. The glucose is subsequently phosphorylated to glucose-6-phosphate by hexokinase . 6. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. 7. Important for glycolysis to proceed, the hexokinase reaction activates glucose for subsequent steps. 8. TIGAR binds hexokinase 2 and increases its activity by an as yet unknown mechanism. 9. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase . 10. In hypoxic tumors, hexokinase mRNA abundance is significantly increased as well as protein levels.
