31. The inclusion bodies can first be identified by light microscopy in patient blood smears or stained sections of infected tissues. 32. In addition, plant viruses make inclusion bodies in plant cells that can be stained and seen in a light microscope. 33. Also, many proteins become insoluble as inclusion bodies that are difficult to recover without harsh denaturants and subsequent cumbersome protein-refolding. 34. Vimentin has been shown to eliminate toxic proteins in JUNQ and IPOD inclusion bodies in asymmetric division of mammalian cell lines. 35. When present, dysphagia is a progressive condition in patients with inclusion body myositis and often leads to death from aspiration pneumonia. 36. In 1951 his research included histochemistry of viral and non-viral inclusion bodies and he continued to study chemical fixatives and fixation techniques. 37. In contrast, the inclusion body shape, distribution of viral particles within the cytoplasm and overall appearance of lymphocystis nodules varied by species. 38. The condition now called Desmin-related myofibrillar myopathy ( also called myofibrillar myopathy-1 ) was formerly called inclusion body myopathy 1 ( IBM1 ). 39. In Pick's disease and corticobasal degeneration tau proteins are deposited in the form of inclusion bodies within swollen or " ballooned " neurons. 40. Impaired proteasomal activity may underlie cognitive disorders such as the autism spectrum disorders, and muscle and nerve diseases such as inclusion body myopathy.