41. Abnormal neuroserpin proteins can attach to one another and form clumps ( called neuroserpin inclusion bodies or Collins bodies ) within nerve cells. 42. Parkin is the protein that, in the protein ligase function, forms Lewy bodies ( the regular wild-type protein localized to inclusion bodies ). 43. In 1871, he was the first scientist to describe " Schaumann bodies ", structures that are defined as being cytoplasmic calcium inclusion bodies. 44. There are two types : sporadic inclusion body myositis ( sIBM ), which is more common, and hereditary inclusion body myopathy ( hIBM ). 45. There are two types : sporadic inclusion body myositis ( sIBM ), which is more common, and hereditary inclusion body myopathy ( hIBM ). 46. Because they do not display inflammation as a primary symptom, they may in fact be similar, but different diseases to sporadic inclusion body myositis. 47. It has been suggested that inclusion bodies are dynamic structures formed by an unbalanced equilibrium between aggregated and soluble proteins of " Escherichia coli ". 48. Such infants may develop acute neonatal conjunctivitis within a few days of birth, and smears from their eyes reveal the presence of characteristic inclusion bodies. 49. However, not all proteins formed may be soluble in the cytoplasm, and incorrectly folded proteins formed in cytoplasm can form insoluble aggregates called inclusion bodies. 50. April 2016 Novartis said that its breakthrough drug bimagrumab ( BYM338 ) failed a Phase IIb / III study for sporadic inclusion body myositis.