1. Transgenic gene knockout mice lacking MAPK1 have major defects in early development. 2. The major defects are multiple twins, as suggested by High-resolution transmission electron microscopy. 3. Major defects can result in the product's failure, reducing its marketability, usability or saleability.4. Omission of planning from the purview of the district councils was another major defect . 5. The current system, although far superior to what went before, has two major defects . 6. Its major defect is equity : flat taxes bestow huge tax cuts on wealthy families. 7. And here as elsewhere the reader comes up against one of the book's major defects . 8. It is not a major defect , he said. 9. Suddenly, a major defect in the site title was discovered, and a new site was purchased. 10. :: : " In hindsight, I believe that the Court s opinion had two major defects .
