1. Nalidixic acid is effective primarily against gram-negative bacteria, with minor anti-gram-positive activity.2. For example, WIN 18, 320 was nalidixic acid , the first quinolone antibiotic. 3. Quinolones ( including nalidixic acid and ciprofloxacin ) have this function. 4. They are very sensitive to ampicillin and resistant to kanamycin and nalidixic acid . 5. Most of the strains studied are resistant to ampicillin, kanamycin and nalidixic acid . 6. Other drugs can also be used, significant ones being chloramphenicol, streptomycin, and nalidixic acid . 7. They proved to be only marginal improvements over nalidixic acid . 8. The subunit A is selectively inactivated by antibiotics such as oxolinic and nalidixic acids . 9. It is resistant to cephalothin and nalidixic acid . 10. The first quinolone was nalidixic acid -introduced in 1962 for treatment of urinary tract infections in humans.
