1. Bone morphogenic proteins ( BMPs ) are important regulators of optic cup development. 2. The middle portion of the optic cup develops into the ciliary body and iris. 3. The optic vesicles then begin to form the optic cup . 4. The final 18 hours involve continuing this apically convex invagination to form the optic cup . 5. Iris is formed from the optic cup cells. 6. In 2012, Sasai became the first stem cell researcher to grow an optic cup from human cells. 7. Interactions between tissues and signaling pathways also play a major role in morphogenesis of the optic cup . 8. In fact, research studies have shown that BMP agonists and antagonists are necessary for precision of optic cup development. 9. The " fgf " 8 mRNA becomes localized in what differentiates into the neural retina of the optic cup . 10. Further differentiation and mechanical rearrangement of cells in and around the optic cup gives rise to the fully developed eye.
