1. Meticillin is actually a penicillinase -resistant B-lactam antibiotic. 2. Penicillinase production is one mechanism by which bacteria can become penicillin resistant.3. TEM-1 is a penicillinase specific for penicillins. 4. Methicillin is a derivative of penicillin that was created to resist the penicillinase enzyme. 5. More than 50 % of the isolates taken from infected patients contain the penicillinase enzyme. 6. The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms. 7. With his colleagues, he also discovered penicillinase , a penicillin-destroying enzyme that disclosed much about resistance to penicillin. 8. Penicillinase -resistant beta-lactams such as methicillin were developed, but there is now widespread resistance to even these.9. Meticillin is insensitive to beta-lactamase ( also known as penicillinase ) enzymes secreted by many penicillin-resistant bacteria. 10. Meticillin is not bound and hydrolysed by penicillinase , meaning it can kill the bacteria, even if this enzyme is present.
