1. The dendrites spread outwards from ipRGCs within the inner plexiform layer. 2. The external plexiform layer contains astrocytes, interneurons and some mitral cells. 3. The most superficial layer of the cortex is the molecular or plexiform layer. 4. This signaling happens before bipolar cells form connections in the inner plexiform layer. 5. It is being studied to treat plexiform neurofibromas. 6. This forms a plexiform network of blood vessels. 7. Removal of plexiform neurofibromas is difficult because they can be large and cross tissue boundaries. 8. Sorafenib is being studied for treatment of unresectable plexiform neurofibroma and low-grade astrocytomas. 9. Plexiform neurofibromas have the potential to cause severe clinical complications if they occur in certain areas.10. However, besides pain, plexiform neurofibromas are sometimes removed due to the possibility of malignant transformation.
