Tachyphylaxis and tolerance have been demonstrated with all drugs of this class.
2.
A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time ( tachyphylaxis ).
3.
Dual reuptake inhibitors, also known as tricyclic antidepressants have been shown to have lower rates of tachyphylaxis.
4.
To prevent tachyphylaxis, a topical steroid is often prescribed to be used on a week on, week off routine.
5.
However, the effectiveness of glyceryl trinitrate is limited by development of tolerance / tachyphylaxis within 2 3 weeks of sustained use.
6.
In addition, a fairly rapid tachyphylaxis can develop within 6 weeks of initiation of treatment, further limiting its potential for long-term use.
7.
Various ramp stimulations ( Fig . 3 ) show the typical feature of tachyphylaxis, namely, the faster the ramp, the higher is the temporary response.
8.
Repeated application can result in tachyphylaxis ( reduced effectiveness ) due to the formation of anti-mouse antibodies in the patient, which accelerates elimination of the drug.
9.
Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis ( " a rapid decrease in the response to a drug after repeated doses over a short period of time " ).
10.
Ibopamine eye drop at 2 % concentration, containing 1 mg of the compound, did not show any significant systemic side-effects and tachyphylaxis phenomena whereas the oral dosage is higher than 400 mg per day.
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