aldose sentence in Hindi
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- In diabetics, the lack of insulin leads to production of an enzyme called aldose reductase, which creates a sugar that does the damage.
- Pfizer's drug, Alond, and Warner-Lambert's Zenarestat, are pills and attack neuropathy by inhibiting aldose reductase production.
- An aldose differs from a ketose in that it has a carbonyl group at the end of the carbon chain instead of in the middle.
- Polyol pathway scheme depicting both the NADPH-dependent reduction step catalyzed by aldose reductase and the NAD +-induced oxidation catalyzed by sorbitol dehydrogenase
- It has a terminal aldehyde group rather than a ketone in its linear chain, and so is considered part of the aldose family of monosaccharides.
- The systematic name of this enzyme class is "'NDP : alpha-D-aldose-1-phosphate nucleotidyltransferase " '.
- The systematic name of this enzyme class is "'NTP : alpha-D-aldose-1-phosphate nucleotidyltransferase " '.
- While it does provide access to every possible stereoisomer of any desired aldose, the process is limited in by its low yield and use of toxic reagents.
- At equilibrium the aldose and ketose form a mixture which in the case of the glyceraldehyde and dihydroxyacetone is also called "'glycerose " '.
- A reducing end of a carbohydrate is a carbon atom that can be in equilibrium with the open-chain aldehyde ( aldose ) or keto form ( ketose ).
- If the carbonyl is at the very beginning of the chain ( carbon 1 ), the monosaccharide is said to be an aldose, otherwise it is a ketose.
- Alrestat was first synthesized in 1969 and was the first aldose reductase inhibitor ( ARI ) with oral bioavailability to undergo clinical trials, in the late 1970s and early 1980s.
- Rough mechanism showing cis-enediol intermediateMPI must convert an aldose ( mannose ) to a ketose ( fructose ), in addition to opening and closing the rings for these sugars.
- Natural sources reported to inhibit aldose reductase include indian gooseberry, spinach, cumin seeds, fennel seeds, basil leaves, lemon, black pepper, curry leaves, cinnamon and lichen.
- A laboratory synthesis of a uronic acid from an aldose requires protecting the aldehyde and hydroxy groups from oxidation, for example by conversion to cyclic acetals ( e . g ., acetonides ).
- In a hyperglycemic state, the affinity of aldose reductase for glucose rises, causing much sorbitol to accumulate, and using much more NADPH, leaving less NADPH for other processes of cellular metabolism.
- By 1928, he had deduced and confirmed the structures of maltose, cellobiose, lactose, gentiobiose, melibiose, gentianose, raffinose, as well as the glucoside ring tautomeric structure of aldose sugars.
- Examples of aldose include glycolaldehyde, glyceraldehyde, erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, talose, and galactose.
- However, there are a few exceptions to this general rule, and enzymes such as aldose reductase, glucose-6-phosphate dehydrogenase, and methylenetetrahydrofolate reductase can use both coenzymes in some species.
- In carbohydrate chemistry, the Lobry de Bruyn van Ekenstein transformation is the base or acid-catalyzed transformation of an aldose into the ketose isomer or vice versa, with a tautomeric enediol as reaction intermediate.
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