duplex dna sentence in Hindi
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- The APE2 3' 5'exonuclease activity has the ability to hydrolyze blunt-ended duplex DNA, partial DNA duplexes with a recessed 3'- terminus or a single nucleotide gap containing heteroduplex DNA . The APE2 3'- phosphodiesterase activity can remove modified 3'- termini, such as 3'- phosphoglycolate as well as mismatched nucleotides from the 3'primer end of DNA.
- Additionally, in 2011, the human thymine DNA glycosylase ( hTDG ) was reported to efficiently excises 5-formylcytosine ( 5fC ) and 5-carboxylcytosine ( 5caC ), the key oxidation products of 5-methylcytosine in genomic DNA . Later on, the crystal structure of the hTDG catalytic domain in complex with duplex DNA containing 5caC was published, which supports the role of TDG in mammalian 5-methylcytosine demethylation.
- Studies on the effects of the length of the primer strand reveal that an equilibrium mixture of four hybridization conformations was observed when template bases looped-out as a bulge, i . e . a structure flanked on both sides by duplex DNA . In contrast, a double-loop structure with an unusual unstacked DNA conformation at its downstream edge was observed when the extruded bases were positioned at the primer template junction, showing that misalignments can be modified by neighboring DNA secondary structure.
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