erythropoiesis sentence in Hindi
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- The contribution of Epo and EpoR to neuroprotection and development are not as clearly understood as its role in erythropoiesis in hematopoietic tissue.
- The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.
- Lack of either causes maturation failure in the process of erythropoiesis, which manifests clinically as reticulocytopenia, an abnormally low amount of reticulocytes.
- However, KLF2 and EKLF have been found to interact in embryonic erythropoiesis . ?-globin and ?-globin in embryonic proerythroblasts.
- Erythropoiesis impairment begins when the serum iron level falls to less than 50 ?g / dL and transferrin saturation is less than 16 %.
- Recent studies have also shown that the peptide hormone hepcidin may play a role in the regulation of hemoglobin production, and thus affect erythropoiesis.
- Erythroferrone, produced in erythroblasts, has been identified as inhibiting hepcidin and so providing more iron for hemoglobin synthesis in situations such as stress erythropoiesis.
- These mice exhibit elevated erythropoiesis consistent with the idea that phosphatase recruitment ( and therefore the shutting down of signaling ) is aberrant in these mice.
- KLF2 is now believed to play an important role in embryonic erythropoiesis, specifically in regulating embryonic and adult ?-globin gene expression was unaffected.
- Clinical research studies where the NHP was utilized include investigations into erythropoiesis-stimulating agents, glucocorticoid replacement therapy and transcutaneous electrical nerve stimulation for tinnitus.
- Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe.
- In most instances, the macroovalocyte morphology is due to megaloblastic erythropoiesis ( Vitamin B-12 or folate deficiency ) but may be seen with dyserythropoiesis.
- Before anemia occurs, the medical condition of Iron Deficiency without anemia is called Latent Iron Deficiency ( LID ) or Iron-deficient erythropoiesis ( IDE ).
- In the process of erythropoiesis ( red blood cell formation ), reticulocytes develop and mature in the bone marrow and then stains such as new methylene blue.
- Mice with truncated EpoR are viable, which suggests Jak2 activity is sufficient to support basal erythropoiesis by activating the necessary pathways without phosphotyrosine docking sites being needed.
- Loss of function of the erythropoietin receptor or JAK2 in mice cells causes failure in erythropoiesis, so production of red blood cells in embryos and growth is disrupted.
- However approximately 20 percent comes from other heme sources, including ineffective erythropoiesis, and the breakdown of other heme-containing proteins, such as muscle myoglobin and cytochromes.
- Red blood cells of mammals cells have nuclei during early phases of erythropoiesis, but extrude them during development as they mature in order to provide more space for hemoglobin.
- Mice with increased hepcidin expression also demonstrated an increase in the lifespan of their red cells, reversal of ineffective erythropoiesis and splenomegaly, and an increase in total hemoglobin levels.
- Increased gastrointestinal iron absorption is seen in all grades of beta thalassemia and increased red blood cell destruction by the spleen due to ineffective erythropoiesis further releases additional iron into the bloodstream.
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