frameshift mutation sentence in Hindi
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- In prostate cancer a frameshift mutation changes the open reading frame ( ORF ) and prevents apoptosis from occurring.
- During testing of coding regions to identify mutations, 116 genetic variants were discovered, including 61 frameshift mutations.
- It may be interesting to touch on how frameshift mutation rates can vary based on positioning within the genome.
- A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids.
- The frameshift mutations lead to an early stop codon which is known to play a role in the disease in infants.
- The effects of neighboring bases and secondary structure to detect the frequency of frameshift mutations has been investigated in depth using fluorescence.
- This could use disablement detection, which looks for nonsense or frameshift mutations that would truncate or collapse an otherwise functional coding sequence.
- Reverse transcriptase, as opposed to RNA Polymerase II, is thought to be a stronger cause of the occurrence of frameshift mutations.
- Experiments can be run to determine the frequency of the frameshift mutation by adding or removing a pre-set number of nucleotides.
- The other three are missense mutations and frameshift mutations, which lead to a shortening of amino acid sequence in the C terminus.
- Within the talk section there is some discussion about how impactful frameshift mutations are concerning the structure of proteins resulting from gene expression.
- An experiment to determine the accuracy of this newer sequencing method tested for 21 genes and had no false positive calls for frameshift mutations.
- The methods include providing a tissue or fluid sample and conducting gene analysis for frameshift mutation or a protein from this type of mutation.
- A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted.
- Such frameshift mutations can lead to deleterious effects on the peptide chain, including insertion of different amino acids or premature truncation of the protein.
- Mutations that disrupt the reading frame sequence by indels ( deletions ) of a non-multiple of 3 nucleotide bases are known as frameshift mutations.
- Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial.
- An environmental study, specifically the production of UV-induced frameshift mutations by DNA polymerases deficient in 32 ?! 52 exonuclease activity was done.
- The mutants produced by Crick and Brenner could not produce functional rIIB protein because the insertion or deletion of a single nucleotide caused a frameshift mutation.
- However, many other genes have been discovered which did evolve by gene duplication followed by a frameshift mutation affecting at least part of the gene.
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