hemoglobinuria sentence in Hindi
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- Quinine may also trigger a rare form of hypersensitivity reaction in malaria patients termed blackwater fever that results in massive hemolysis, hemoglobinemia, hemoglobinuria, and renal failure.
- She suggested the use of eculizumab, a humanized monoclonal antibody drug developed by Alexion Pharmaceuticals and approved by the Food and Drug Administration for treatment of Paroxysmal nocturnal hemoglobinuria.
- Paroxysmal nocturnal hemoglobinuria is caused by complement breakdown of RBCs due to an inability to make GPI . Thus the RBCs are not protected by GPI anchored proteins such as DAF.
- A hemolytic reaction can occur between 3 and 14 days as a result of a secondary immune response, with a drop in hemoglobin level, fever, jaundice, or hemoglobinuria.
- Genetic defects in GPI-anchor attachment that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal nocturnal hemoglobinuria ( PNH ).
- The Dutch physician Enneking coined the term " paroxysmal nocturnal hemoglobinuria " ( or " haemoglobinuria paroxysmalis nocturna " in Latin ) in 1928, which has since become the default description.
- Hemoglobinuria is another indicator of intravascular hemolysis, but disappears more quickly than hemosiderin, which can remain in the urine for several weeks; therefore, hemosiderinuria is a better marker for intravascular hemolysis.
- His name is lent to " Winckel's disease ", a disease originally described in the epidemic form in 1879 . It has been referred to as " epidemic hemoglobinuria of the newborn ".
- Paroxysmal nocturnal hemoglobinuria ( PNH ) is a rare condition resulting from acquired alterations in the " PIGA " gene, which plays a role in the protection of blood cells from the complement system.
- Myoglobin was demonstrated in the urine of victims by spectroscopy, and it was noted that the kidneys of victims resembled those of patients who had hemoglobinuria ( hemoglobin rather than myoglobin being the cause of the kidney damage ).
- Patients suffering from paroxysmal nocturnal hemoglobinuria ( PNH ) appear to be especially at risk for Budd Chiari syndrome, more than other forms of thrombophilia : up to 39 % develop venous thromboses and 12 % may acquire Budd-Chiari.
- A urine test strip showing positive for blood can also indicate hemoglobinuria, which is not detectable using a microscope due to the lysis of red blood cells in the urinary tract ( particularly in alkaline or dilute urine ), or intravascular hemolysis.
- "' Alexion Pharmaceuticals Inc . "'is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome ( aHUS ) and paroxysmal nocturnal hemoglobinuria ( PNH ).
- Many patients with aplastic anemia also have clones of cells characteristic of the rare disease paroxysmal nocturnal hemoglobinuria ( PNH, anemia with thrombopenia and / or thrombosis ), sometimes referred to as AA / PNH . Occasionally PNH dominates over time, with the major manifestation intravascular hemolysis.
- They are usually associated with multiple sclerosis or pertussis, but they may also be observed in other trauma, stroke, asthma, trigeminal neuralgia, breath-holding spells, epilepsy, malaria, tabes dorsalis, and Beh�et's disease, paroxysmal nocturnal hemoglobinuria ( PNH ).
- "' David L . Hallal "'is the former President and Chief Executive Officer ( CEO ) of Alexion Pharmaceuticals, the American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome ( aHUS ) and paroxysmal nocturnal hemoglobinuria ( PNH ).
- Decreased platelet numbers may be due to various causes, including insufficient production ( e . g ., in myelodysplastic syndrome or other bone marrow disorders ), destruction by the immune system ( immune thrombocytopenic purpura / ITP ), and consumption due to various causes ( thrombotic thrombocytopenic purpura / TTP, hemolytic-uremic syndrome / HUS, paroxysmal nocturnal hemoglobinuria / PNH, disseminated intravascular coagulation / DIC, heparin-induced thrombocytopenia / HIT ).
- In December 2014 the provincial government of Ontario, Canada was in ongoing price negotiations with the Soliris manufacturer, the only drug approved by Health Canada to treat aHUS . Patients who require the apply for it on " compassionate grounds " " on a case-by-case basis for individuals who have been urgently hospitalized due to an immediate life-, limb-, or organ-threatening complication . " Soliris is already " funded by the Ontario government for the treatment of another rare illness, paroxysmal nocturnal hemoglobinuria ( PNH ), through a bulk-buy deal reached by the provincial premiers in 2011 ."
- Eculizumab was approved by the U . S . Food and Drug Administration ( FDA ) on March 13, 2007 for the treatment of paroxysmal nocturnal hemoglobinuria ( PNH ), a rare, progressive, and sometimes life-threatening disease characterized by excessive hemolysis; and on September 23, 2011 for the treatment of atypical hemolytic uremic syndrome ( aHUS ) It was approved by the European Medicines Agency for the treatment of PNH on June 20, 2007, and on November 29, 2011 for the treatment of aHUS . However, of note is the exceedingly high cost of treatment, with one year of the drug costing over $ 500, 000.
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