hemophilia a sentence in Hindi
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- It is a synthetic version of the naturally occurring coagulation protein that is missing or deficient in people with hemophilia A, an ailment that affects about 13, 000 Americans.
- Cohen said protein injections to curb hemophilia A represent a market of $ 1 . 6 billion in the United States, more than four times the market for hemophilia B.
- The new drug is a synthetic, genetically engineered version of the naturally occurring coagulation protein that is missing or deficient in people with hemophilia A, a condition affecting about 14, 000 Americans.
- Its specialty is providing physicians with DNA tests for people who may be carriers of rare inherited diseases such as cystic fibrosis, Huntington's disease, Tay-Sachs disease, hemophilia A and sickle cell anemia.
- Even so, by getting in with Avigen now, Bayer presumably gets a leg up on a future licensing deal, if and when the Alameda firm makes gene therapy possible for hemophilia A.
- For 43 years, Miller has been going to the hospital for treatment of hemophilia A, a disease that prevents his blood from clotting and causes severe bleeding in his joints and body cavities.
- Nevertheless, Avigen is doing research on delivering the Factor VIII gene with the adeno-associated virus, and expects to seek permission from the FDA to begin a clinical trial in hemophilia A next year.
- The company already has an FDA-approved recombinant product on the market for patients with the more common Hemophilia A . Those patients suffer from the absence of a different naturally occurring blood factor.
- Avigen is already performing animal tests of a gene therapy for the more common form of hemophilia A . The company hopes to begin testing this new gene therapy on human patients in 2001.
- Such X-linked Mendelian diseases include Duchenne muscular dystrophy ( DMD ), and hemophilia A and B, which are rarely seen in females because the offspring is unlikely to inherit two copies of the recessive allele.
- However, the study was designed only to test safety, not the effectiveness of the treatment aimed at the 13, 500 Americans who have severe hemophilia A, a form of the genetic disease that causes excessive bleeding.
- Factor VIII turned out to be deficient in the clinically recognised but etiologically elusive hemophilia A; it was identified in the 1950s and is alternatively called " antihemophilic globulin " due to its capability to correct hemophilia A.
- One of the keys to understanding the rationale behind the Bayer-Avigen collaboration is visible from Interstate 80 in Berkeley, Calif ., where Bayer employs 1, 400 people at a plant that makes the clotting proteins for hemophilia A.
- Factor VIII turned out to be deficient in the clinically recognised but etiologically elusive hemophilia A; it was identified in the 1950s and is alternatively called " antihemophilic globulin " due to its capability to correct hemophilia A.
- "These are the first positive results from a trial of gene therapy for hemophilia A, " which causes abnormal bleeding in about 13, 500 Americans, said Dr . David Roth of Beth Israel Deaconess Medical Center, the principal investigator.
- The Chiron Corporation, a biotechnology company based in Emeryville, Calif ., has treated eight hemophilia A patients with a gene therapy using a retrovirus as a vector, and plans to release its first data by the middle of next year.
- The recently disclosed files also contained a June 7 memo on blood products for Hemophilia A, which stated that if the Japanese Red Cross provided 44 percent of plasma to medical institutions, an ample supply of safer domestic blood products would be made available.
- Hemophilia B, less common than hemophilia A, is a gender-linked bleeding disorder caused by the absence or deficiency of the blood clotting protein factor IX . According to the World Hemophilia Foundation, one in 10, 000 males born worldwide has hemophilia, which afflicts about 400, 000 people worldwide.
- The usefulness of desmopressin in hemophilia A depends predominantly on whether the deficiency involved is qualitative ( i . e ., there is a functional mutation of the protein itself ) or quantitative ( i . e ., there is decreased production of a functionally normal protein ).
- Factor XII does play an important role in clot formation during " in vitro " measurements of the partial thromboplastin time, which causes these measurements to be markedly prolonged in patients with factor XII deficiency, usually well beyond even what is seen in hemophilia A, hemophilia B, or factor XI deficiency.
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