macula densa sentence in Hindi
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- Second, macula densa cells release prostaglandins, which triggers granular juxtaglomerular cells lining the afferent arterioles to release renin into the bloodstream . ( The juxtaglomerular cells can also release renin independently of the macula densa.
- In the kidneys, the glomerular filtration rate ( GFR ) is regulated by several mechanisms including tubuloglomerular feedback ( TGF ), in which an increased distal tubular sodium chloride concentration causes a basolateral release of ATP from the macula densa cells.
- Macula densa cells sense changes in sodium chloride level, and will trigger an autoregulatory response to increase or decrease reabsorption of ions and water to the blood ( as needed ) in order to alter blood volume and return blood pressure to normal.
- The macula densa senses this drop in salt concentration and responds through two mechanisms : First, it triggers dilation of the renal afferent arteriole, decreasing afferent arteriole resistance and, thus, offsetting the decrease in glomerular hydrostatic pressure caused by the drop in blood pressure.
- As part of the body s blood pressure regulation, the macula densa monitors filtrate osmolarity; if it falls too far, the macula densa causes the afferent arterioles of the kidney to dilate, thus increasing the pressure at the glomerulus and increasing the glomerular filtration rate.
- As part of the body s blood pressure regulation, the macula densa monitors filtrate osmolarity; if it falls too far, the macula densa causes the afferent arterioles of the kidney to dilate, thus increasing the pressure at the glomerulus and increasing the glomerular filtration rate.
- When the macula densa detects an elevated GFR, it releases several molecules that cause the glomerulus to rapidly decrease its filtration rate . ( Technically, the macula densa detects a SNGFR, single nephron GFR, but " GFR " is used here for simplicity .)
- When the macula densa detects an elevated GFR, it releases several molecules that cause the glomerulus to rapidly decrease its filtration rate . ( Technically, the macula densa detects a SNGFR, single nephron GFR, but " GFR " is used here for simplicity .)
- Renin cleaves the peptide bond between the leucine ( Leu ) and valine ( Val ) residues on angiotensinogen, creating the ten-amino acid peptide ( des-Asp ) angiotensin I . Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure ( < 90mmHg systolic blood pressure ) at the juxtaglomerular cells, or decreased delivery of Na + and Cl-to the macula densa.
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