nicotinic acid sentence in Hindi
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- The most common side effect of high-dose nicotinic acid is flushing, which can occur at 100 milligrams of immediate-release forms and at higher doses of slow-release forms.
- It is an ester of pentaerythritol and nicotinic acid, has general properties similar to those of nicotinic acid ( Nicotinamide ), to which it is slowly hydrolysed.
- It is an ester of pentaerythritol and nicotinic acid, has general properties similar to those of nicotinic acid ( Nicotinamide ), to which it is slowly hydrolysed.
- Metabolic studies show that the pyridine ring of nicotine is derived from niacin ( nicotinic acid ) while the pyrrolidone is derived from " N "-methyl-? 1-pyrrollidium cation.
- He labored with unremitting zeal to put thiamine, nicotinic acid, riboflavin, folic acid, vitamin B12 and thymine ( 5-methyl uracil ) to use in clinical and preventive medicine.
- Nicotinic acid and niacinamide are convertible to each other with steady world demand rising from 8, 500 tonnes per year in the 1980s to 40, 000 in recent years.
- It is an isomer of picolinic acid and nicotinic acid which has the carboxyl group at the 2nd and 3rd position respectively compared to the 4-position for nicotinic acid.
- In 1958, Jack Preiss and Philip Handler discovered the intermediates and enzymes involved in the biosynthesis of NAD; consequently, salvage synthesis from nicotinic acid is termed the Preiss-Handler pathway.
- Research carried out in 1989 found PGD 2 is the primary mediator of vasodilation ( the " niacin flush " ) after ingestion of niacin ( nicotinic acid ).
- It is an isomer of picolinic acid and nicotinic acid which has the carboxyl group at the 2nd and 3rd position respectively compared to the 4-position for nicotinic acid.
- In alternate terminology, it is known as " nicotinic acid diethylamide ", which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.
- Flushing occurs in many patients treated therapeutically with nicotinic acid, and as a result, nicotinamide holds more clinical value as it is not associated with the same uncomfortable flushing.
- For example, the enzyme nicotinamidase, which converts nicotinamide to nicotinic acid, is a target for drug design, as this enzyme is absent in humans but present in yeast and bacteria.
- This form of niacin is supposed to reduce or prevent flushing by being broken down into the metabolites Niacin ( aka Nicotinic acid ) and Inositol at a slower rate.
- High dose nicotinic acid is used as an agent that elevates high-density lipoprotein cholesterol, lowers low-density lipoprotein cholesterol and lower free fatty acids through a mechanism that is not completely understood.
- The product of this reaction, phosphoribosyl pyrophosphate ( PRPP ), is used in numerous biosynthesis ( NAD : the reaction of PRPP with nicotinic acid yields the intermediate nicotinic acid mononucleotide.
- Conrad Elvehjem isolated nicotinic acid ( niacin ) at the Agricultural Chemistry Building in 1937, which cured pellagra . and Karl Paul Link identified the blood coagulant dicumarol here in 1941.
- The product of this reaction, phosphoribosyl pyrophosphate ( PRPP ), is used in numerous biosynthesis ( NAD : the reaction of PRPP with nicotinic acid yields the intermediate nicotinic acid mononucleotide.
- Cholesterol is the main constituent of atheroma, the fatty lumps in the wall of dietary measures, such as a low-fat diet, and poorly tolerated medicines, such as clofibrate, cholestyramine, and nicotinic acid.
- Leete at al further refined this model in 1989, and showed that it was trigonelline ( nicotinic acid methylated at the nitrogen ) that served as an intermediate in the biosynthesis of dioscorine.
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