null allele sentence in Hindi
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- Mutations in " CPOX " usually cause hereditary coproporphyria, an acute hepatic porphyria, however the K404E mutation in a homozygous or compound heterozygous state with a null allele cause the more severe harderoporphyria.
- A mouse expressing a null allele of the " ITGA7 " gene are viable, suggesting that alpha-7 integrin is not essential for normal myogenesis; however, these mice develop a phenotype that resembles muscular dystrophy.
- In many cases, strains carrying one of two types of alleles will be archived-a null allele used in the primary IMPC phenotyping pipeline and a conditional ready allele that allows tissue restricted knockouts via the Cre-Lox Recombination and FLP-FRT recombination systems.
- Individuals who are homozygous for a specific mutation ( K404E ) or compound heterozygous with a null allele in " CPOX " have a more severe erythropoietic porphyria, harderoporphyria, characterized by neonatal jaundice, hyperbilirubinemia, hepatosplenomegaly and skin lesions upon exposure to ultraviolet light.
- However they also found that if you have just one null allele ( what we call heterozygous for that gene ), then you may have a different hair colour on your head, but that you have an an increased likelihood of having red body hair.
- Typically need your null allele to be incorporated into the DNA from a strain with a different coat colour, since this is the way you can identify your founders ( 129 mice are white, and B6 mice are black-chimeric mice will be a patchwork of white and black ).
- CYP2C19 * 2 ( 19154G > A, rs4244285, Il264Met ) and CYP2C19 * 3 ( 17948G > A, rs4986893, His212X ) are loss-of-function null alleles; carriers of the CYP2C19 * 3 but not the CYP2C19 * 2 allele showed a " reduced " risk of developing essential hypertension in a large Korean population study.
- And then you can define that section, whether it is a null allele with a DNA deletion or a gene duplication or some more complicated scramble, as an " allele ", and say that one organism has that allele while the other has the boring allele with one copy of the gene you expect.
- An HLA allele coding non-expressed gene is termed " Null Allele ", for example : HLA-B * 15 : 01 : 01 : 02N . The expression level can also detected by serotyping, an HLA gene coding for antigens which has low protein expression on the cell surface is termed " Low Expresser ", for example : HLA-A * 02 : 01 : 01 : 02L.
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