polyprotein sentence in Hindi
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- The Gag polyprotein is cleaved into matrix ( MA ), capsid ( CA ) and nucleocapsid ( NC ) proteins.
- Four nonstructural proteins ( nsP1-4 ) which are produced as a single polyprotein constitute the virus'replication machinery.
- The Env polyprotein consists of a leader peptide ( L ), surface ( SU ) and transmembrane ( TM ) glycoproteins.
- The preferred, native cleavage sequence was first identified by examining the cut sites in the native polyprotein substrate for recurring sequence.
- :Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond.
- Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly.
- ASLV and some RSVs also contain the " env " gene, which encodes a precursor polyprotein that assembles in the endoplasmic reticulum.
- The p24 capsid protein ( CA ) is a 24 kDa protein fused to the C-terminus of MA in the unprocessed HIV Gag polyprotein.
- Retroviral aspartyl protease is synthesised as part of the POL polyprotein that contains; an aspartyl protease, a reverse transcriptase, RNase H and integrase.
- The rest of the genome encodes structural proteins at the 5'end and non-structural proteins at the 3'end in a single polyprotein.
- The processing of the polyprotein occurs in a highly regulated manner, with cleavage at the P2 / 3 junction influencing RNA template use during genome replication.
- As opposed to alpha viruses the capsid does not undergo autoprotolysis, rather is it cut off from the rest of the polyprotein by the signal-peptidase.
- Blood clotting ( such as thrombin ) and viral polyprotein processing ( such as TEV protease ) requires this level of specificity in order to achieve precise cleavage events.
- Despite occupying 7.3 % of the polyprotein it is responsible for 26.2 % to 33.3 % of the variation found between the Iflaviridae.
- The HIV nucleocapsid protein ( NC ) is a 7 kDa zinc finger protein in the Gag polyprotein and which, after viral maturation, forms the viral nucleocapsid.
- The polyprotein coat of CfMV is made up of two proteins, encoded by overlapping open reading frames ( 2a and 2b ) which are transcribed through a ribosomal frameshift mechanism.
- This polyprotein is proteolytically processed by viral proteases ( NIa, HC-Pro and P1 ) and undergoes co-and posttranslational cleavage to yield several multi-functional proteins.
- The " env " gene is translated into a single precursor polyprotein that is cleaved by a host protease into two proteins, the surface glycoprotein and the transmembrane glycoprotein.
- As a result, the HIV-1 ribosomal frameshift signal is highly regulated, as it modulates the expression levels of the Gag protein relative to the Gag-Pol polyprotein.
- Cyclophilin A is also known to be recruited by the Gag polyprotein during HIV-1 virus infection, and its incorporation into new virus particles is essential for HIV-1 infectivity.
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