pyrrolidine sentence in Hindi
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- A later team at Zambon modified the pyrrolidine with a pyrrolidone could produce an analogue some 318x morphine in its analgesic activity in animal studies ( the latter overlays beta hydroxy fentanyl ).
- Some trials have been made, e . g . by replacing the pyrrolidine with a polar negatively charged side-chains as well as hydrophilic substitution can lead to excellent inhibitory activity.
- The polar reaction, N-cyclo " pen " tenyl pyrrolidine nucleophilic addition to the diazo compound, proceeds 1, 500 times faster in polar DMSO than in non-polar decalin.
- Then hydroxylation of both the aromatic ring and side chain takes place followed by an oxidation of the pyrrolidine ring to the corresponding lactam, with subsequent detachment and ring opening to the corresponding carboxylic acid.
- The development and modification of Enders'hydrazone alkylation reaction mainly focus on the addition of more steric hindrance on the pyrrolidine rings of both SAMP and RAMP, while preserving the methoxy group for lithium chelation.
- Ring A is synthesized from L-proline through the nonribosomal peptide synthase ( NRPS ) pathway ( figure 2 ), wherein the pyrrolidine ring of proline is oxidized twice through FAD + to yield pyrrole ring A.
- Like its more toxic relatives, " Nicandra physalodes " is alkaloidal, analyses having revealed the presence of the tropane alkaloid tropinone and the pyrrolidine alkaloid hygrine ( 0.1 %, in the root ).
- The main metabolic steps are thought to be demethylenation followed by methylation of one hydroxy group, aromatic and side chain hydroxylation, oxidation of the pyrrolidine ring to the corresponding lactam as well as ring opening to the corresponding carboxylic acid.
- On the other hand, a close analog of this reaction, N-cyclo " hex " enyl pyrrolidine 1, 3-dipolar cycloaddition to dimethyl diazomalonate, is sped up only 41-fold in DMSO relative to decalin.
- In addition, a salt bridge between Glu-97 of thrombin and the amidine group fixed in the pyrrolidine ring of DX-9065a reduces the flexibility of the DX-9065a molecule, which now cannot rotate enough to avoid the electrostatic clash.
- Further investigations demonstrated that both the rate of the ultraviolet-catalyzed decomposition of dibutylchloroamine and the yield of newly formed pyrrolidine are strongly dependent on the acidity of the reaction medium faster and higher-yielding reaction was observed with increasing sulfuric acid concentration.
- "' Pyrrolidine "', also known as "'tetrahydropyrrole "', is an organic compound with the molecular formula ( CH 2 ) 4 NH . It is a cyclic secondary amine, also classified as a saturated heterocycle.
- On the other hand, the stereochemical outcome is reversed with ee selectivities of up to 83 % by using the homologue amino acid catalysts, such as ( S )-?-homoproline, [ ( pyrrolidine-( 2S )-yl ) acetic acid ].
- The reaction is very versatile, consisting in the condensation of an alpha-amino acid and an aldehyde to generate a reactive 1, 3-dipole that then adds to a double bond of C60 or CNT, giving a pyrrolidine ring fused to the carbon skeleton.
- The analog compound with the " N ", " N "-dialkyl substituents constrained into a pyrrolidine ring, is a slightly stronger agonist for the 5-HT 1A receptor and retains the selectivity over the 5-HT 2A / 2C receptors.
- It is more potent than the corresponding pyrrolidine and morpholine analogues ( LPD-824 and LSM-775 respectively ), but is still several times less potent than LSD as a psychedelic in humans, though this does not seem to have been confirmed by any more recent work.
- This catalyst, developed by Itsuno and Elias James Corey, is generated by heating ( " R " )-( + )-2-( diphenylhydroxymethyl ) pyrrolidine along with chiral oxazaborolidine catalysts has been used in the synthesis of commercial drugs such as ezetimibe and aprepitant.
- Phthalimidopropiophenone is not an active stimulant, but is believed to be potentially capable of acting as a prodrug for cathinone when ingested, as similar N-substituted cathinone derivatives have been encountered by law enforcement, and were found to form cathinone " in vivo " by initial hydroxylation of the pyrrolidine ring followed by subsequent dehydrogenation to the corresponding lactam, then by double dealkylation of the pyrrolidine ring to form the primary amine.
- Phthalimidopropiophenone is not an active stimulant, but is believed to be potentially capable of acting as a prodrug for cathinone when ingested, as similar N-substituted cathinone derivatives have been encountered by law enforcement, and were found to form cathinone " in vivo " by initial hydroxylation of the pyrrolidine ring followed by subsequent dehydrogenation to the corresponding lactam, then by double dealkylation of the pyrrolidine ring to form the primary amine.
- So dextromoramide, with a pyrrolidine ring on the 1-amide position, a " dextro " methyl group on the 3-position of the alkyl chain, a morpholine ring around the 4-amine group, and both phenyl rings unsubstituted, was by far the most potent out of all the compounds in this series and was the only one that became widely used in medicine ( although the racemic mix racemoramide saw some limited use ).
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