quinolinic acid sentence in Hindi
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- Lesions in the pallidum can suppress effects of quinolinic acid in monkeys injected with quinolinic acid into their striatum.
- A loss of astrocytes results in a pro-inflammatory effect, further increasing the initial inflammatory response which initiates quinolinic acid production.
- Furthermore, quinolinic acid results in changes of the biochemistry and structure of the astrocytes themselves, resulting in an apoptotic response.
- It is synthesised by the oxidation of aspartate and is condensed by quinolinate synthase with glycerone phosphate to form quinolinic acid.
- Increased levels of quinolinic acid might contribute to the apoptosis of astrocytes and certain neurons, resulting in decreased synthesis of neurotrophic factors.
- High levels of quinolinic acid may be the closest thing so far to a " marker " of child abuse, Kochanek says.
- This is followed by a condensation with glyceraldehyde-3-phosphate and a cyclization catalyzed by quinolinate synthase ( QS ) to give quinolinic acid.
- Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders.
- Because quinolinic acid accumulates slowly in the brain, its presence may reveal whether a parent is lying about the timing of the injury.
- Quinolinic acid then reacts with phosphoriboxyl pyrophosphate catalyzed by quinolinic acid phosphoribosyl transferase ( QPT ) to form niacin mononucleotide ( NaMN ).
- Quinolinic acid then reacts with phosphoriboxyl pyrophosphate catalyzed by quinolinic acid phosphoribosyl transferase ( QPT ) to form niacin mononucleotide ( NaMN ).
- Natural phenols such as catechin hydrate, curcumin, and epigallocatechin gallate reduce the neurotoxicity of quinolinic acid, via anti-oxidant and possibly calcium influx mechanisms.
- Norharmane, via inhibition of indoleamine 2, 3-dioxygenase exerts neuroprotective properties by suppressing kynurenine neurotoxic metabolites such as quinolinic acid, 3-hydroxy-kynurenine and nitric oxide synthase.
- When patients were treated with zidovudine to decrease quinolinic acid levels, the amount of neurological improvement was related to the amount of quinolinic acid decreased.
- When patients were treated with zidovudine to decrease quinolinic acid levels, the amount of neurological improvement was related to the amount of quinolinic acid decreased.
- In addition, increased levels of quinolinic acid could play a role in impairment of the glial-neuronal network, which could be associated with the recurrent and chronic nature of depression.
- This glutamate further stimulates the NMDA receptors, thus acting synergistically with quinolinic acid to increase its neurotoxic effect by increasing the levels of glutamate, as well as inhibiting its uptake.
- The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which may account for the fatigue and malaise observed with Lyme encephalopathy.
- Kochanek and his colleagues could find no trace of quinolinic acid in cerebrospinal fluid taken from 39 adults with head injuries who went to the hospital within 24 hours of being injured.
- His team has studied a range of biochemicals, including amino acids, immune system signaling molecules called cytokines, and quinolinic acid, produced by immune cells that slowly infiltrate the brain after an injury.
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