red cell aplasia sentence in Hindi
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- Peterson said that the company had debated several times whether to take Eprex off the market, as reports of red cell aplasia multiplied, but decided not to do so, concluding that the drug's benefits far outweighed the risks.
- "Our investigation of the employee's allegations confirm that the integrity of our product has never been compromised and there is no connection between the allegations and the occurrence of " pure red cell aplasia, the company said.
- Yet the FDA's thumbs-up for the anti-anemia drug comes at a time when a similar product licensed to Johnson & Johnson via Amgen is under investigation for causing a rare illness called pure red cell aplasia.
- "Our investigation of the employee's allegations confirm that the integrity of our product has never been compromised and there is no connection between the allegations and the occurrence of ( pure red cell aplasia ), " the company said.
- Eprex, which is not sold in the United States, has been linked to 160 cases of pure red cell aplasia, a condition that can destroy patients'ability to make oxygen-carrying red blood cells, leaving them dependent on blood transfusions to survive.
- A report in the New York Times in July said health officials found an increasing number of Eprex users developed pure red cell aplasia, a rare condition in which the body can lose its ability to produce red blood cells, leaving patients dependent on blood transfusions to survive.
- Johnson & Johnson's response has taken several forms : trying to figure out why so many Eprex users have developed red cell aplasia, seeking to shift attention to cases involving its competitors'drugs, and trying to hang on to its lead in the European market.
- A report in the New York Times Friday said health officials have recently found an increasing number of Eprex users have developed pure red cell aplasia, a rare condition in which the body can lose its ability to produce red blood cells, leaving patients dependent on blood transfusions to survive.
- BIOTECH-APLASIA ( Undated )-A small but growing number of patients taking an anemia drug that has been on the market for more than a decade have developed a condition known as pure red cell aplasia in which the body's germ-fighting defenses go haywire and attack its own bone marrow.
- Health authorities in Europe and North America have become increasingly concerned over the last few months about a mysterious rise in the number of Eprex users who have developed pure red cell aplasia, a condition in which the body can lose its ability to produce red blood cells, leaving the patient dependent on blood transfusions to survive.
- Regulators and scientists seeking to explain the cases of red cell aplasia have focused on the Puerto Rico plant, and Johnson & Johnson's competitors _ mainly Amgen, of Thousand Oaks, Calif ., and Roche, of Basel, Switzerland _ say the problem is specific to Eprex, not to their EPO drugs.
- As mentioned earlier, the most common of those conditions is myasthenia gravis ( MG ); 10 15 % of patients with MG have a thymoma and, conversely, 30 45 % of patients with thymomas have MG . Additional associated autoimmune conditions include pure red cell aplasia and Good syndrome ( thymoma with combined immunodeficiency and hypogammaglobulinemia ).
- One clue may have been in the sharp rise in reported cases of red cell aplasia in 1999 . Johnson & Johnson had changed the manufacturing process at the Puerto Rico plant in 1998, ending the use of a human blood protein as a stabilizer in Eprex at the request of European health officials concerned about the spread of mad cow disease.
- J & J-BLOOD-DRUG ( Undated ) _ The discovery that scores of patients who have developed pure red cell aplasia, in which the body's germ-fighting defenses go haywire, had taken a drug made by Johnson & Johnson, has raised doubts about not just the company, but about a whole class of drugs that are a cornerstone of biotechnology.
- Other autoimmune diseases that have been treated with rituximab include autoimmune hemolytic anemia, pure red cell aplasia, thrombotic thrombocytopenic purpura ( TTP ), idiopathic thrombocytopenic purpura ( ITP ), Evans syndrome, vasculitis ( for example granulomatosis with polyangiitis, formerly Wegener's ), bullous skin disorders ( for example pemphigus, pemphigoid with very encouraging results of approximately 85 % rapid recovery in pemphigus, according to a 2006 study ), type 1 diabetes mellitus, Sjogren's syndrome, anti-NMDA receptor encephalitis and Devic's disease, Graves'ophthalmopathy, autoimmune pancreatitis, Opsoclonus myoclonus syndrome ( OMS ), and IgG4-related disease.
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