hemophilia a sentence in Hindi
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- Cryoprecipitate, and later in 1970, lyophilized factor VIII concentrates became available for the treatment of hemophilia A . One of the most frustrating complications in the treatment of hemophilia then, was the development of inhibitors to Factor VIII or Factor IX, which neutralized the activity of the factor given for treatment.
- About 3, 300 people in the United States have hemophilia B, caused by one of several possible mutations in the gene for Factor IX . Another 12, 000 people suffer from hemophilia A, the result of mutations in the gene for Factor VIII, also a vital component of the body's blood-clotting system.
- But let's imagine Avigen is successful in creating a gene therapy for hemophilia A . That one-shot remedy would be a direct threat to Bayer, which has invested $ 350 million in the Berkeley factory over the past few years, and has $ 120 million in new plans on the drawing board.
- Dr . Mark A . Kay, head of the human gene therapy program at Stanford University, said he was " cautiously optimistic " about the early results in both hemophilia A and hemophilia B . But, he said, the treatment will have to be improved to achieve higher levels of the clotting factors.
- If a coagulation factor is part of the contact activation or tissue factor pathway, a deficiency of that factor will affect only one of the tests : Thus hemophilia A, a deficiency of factor VIII, which is part of the contact activation pathway, results in an abnormally prolonged aPTT test but a normal PT test.
- In 2012 the supply agreement with Pfizer for ReFacto / Xyntha was extended until 2020 in addition to the agreement to return the co-promotion rights for the Nordic region for ReFacto to Pfizer for a payment of USD 47.4 M . The same year, the Sobi and partner Biogen Idec initiated global pediatric clinical trials of their long-lasting hemophilia A and B product candidates.
- Diseases often caused by TEs include hemophilia A and B, severe combined immunodeficiency, porphyria, predisposition to cancer, and Duchenne muscular dystrophy . " LINE1 " ( " L1 " ) TEs that land on the human Factor VIII have been shown to cause haemophilia and insertion of " L1 " into the " APC " gene causes colon cancer, confirming that TEs play an important role in disease development.
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