isoenzyme sentence in Hindi
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- Diclofenac has a low to moderate preference to block the COX2-isoenzyme ( approximately 10-fold ) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
- It is suspected that this difference in isoenzyme is due to the predominant pathway the lactate will take-in liver it is more likely to be gluconeogenesis, whereas in the myocardium it is more likely to be oxidation.
- This is mediated via activation of PGC-1alpha which alter the LDH ( lactate dehydrogenase ) isoenzyme complex composition and decreases the activity of the lactate generating enzyme LDHA, while increasing the activity of the lactate metabolizing enzyme LDHB.
- The mitochondrial isoenzyme is involved in the Krebs Cycle ( also known as the Tricarboxylic Acid Cycle [ TCA ] or the Citric Acid Cycle ), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate.
- The mitochondrial isoenzyme is involved in the Krebs Cycle ( also known as the Tricarboxylic Acid Cycle [ TCA ] or the Citric Acid Cycle ), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate.
- Data taken from in vitro human liver microsomes investigating the inhibitory effect of trospium on seven cytochrome P450 isoenzyme substrates ( CYP1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4 ) suggest a lack of inhibition at clinically relevant concentrations.
- As the protein kinase C ( PKC ) isoenzyme family mediates a central cytoprotective effect in the regulation of cell survival, activation of PKC, and subsequent recruitment of numerous downstream elements such as the mitogen-activated protein kinase ( MAPK ) cascade, opposes initiation of the apoptotic cell death program by diverse cytotoxic stimuli.
- Four members of the Daucus genus were examined to determine differences in isoenzyme patterns, and plastid DNA . The four were : " Daucus carota subspecies sativus cultivar Danvers ", " D . carota subsp . gummifer ", " D . capillifolius ", and " D . pusillus ".
- Roxibolone has been found not to bind to the glucocorticoid receptor, and it has been suggested that the antiglucocorticoid activity of roxibolone and formebolone may instead be mediated by IC 50 > 10 ?M ), although it should be noted that this specific isoenzyme of 11?-HSD is responsible for the inactivation of glucocorticoids rather than their production.
- The reverse process of " S "-nitrosylation is termed denitrosylation, which in addition to occurring spontaneously in the presence of metal ions and under conditions of photolysis, has recently been demonstrated to be an enzymically controlled process . " S "-Nitrosoglutathione reductase ( GSNOR ), which accelerates the decomposition of " S "-nitrosoglutathione ( GSNO ) and other SNO-proteins, is an alcohol dehydrogenase class III isoenzyme which has been shown to be conserved from bacteria to humans.
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