opioid peptides sentence in Hindi
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- Although NOP shares high sequence identity ( ~ 60 % ) with the classical opioid receptors ?-OR ( DOR ), it possesses little or no affinity for opioid peptides or morphine-like compounds.
- It has been shown that some experiencing musical frisson report reduced excitement when under administration of naloxone ( an opioid receptor antagonist ), suggesting musical frisson gives rise to endogenous opioid peptides similar to other pleasurable experiences.
- The existence of further opioid receptors ( or receptor subtypes ) has also been suggested because of pharmacological evidence of actions produced by endogenous opioid peptides, but shown not to be mediated through any of the four known opioid receptor subtypes.
- "' Leu-enkephalin "'is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans.
- A significant advantage of inhibiting the breakdown of endogenous opioid peptides rather than stimulating opioid receptors with exogenous drugs is that the levels of opioid peptides are only increased slightly from natural levels, thus avoiding overstimulation and downregulation of the opioid receptors.
- A significant advantage of inhibiting the breakdown of endogenous opioid peptides rather than stimulating opioid receptors with exogenous drugs is that the levels of opioid peptides are only increased slightly from natural levels, thus avoiding overstimulation and downregulation of the opioid receptors.
- Through activation of the KOR, dynorphins, opioid peptides that are the endogenous ligands of the KOR and that can, in many regards, be figuratively thought of as functional inverses of the morphine-like, psychiatric conditions in humans.
- These large dense-core vesicles differ from small synaptic vesicles in that a more intense and prolonged stimulus is needed to cause the large vesicles to release their contents into the synaptic cleft . Dense-core vesicle storage is characteristic of opioid peptides storage.
- These antidepressant effects have been linked to endogenous opioid peptides acting at ? and ? opioid receptors, and so can also be produced by enkephalinase inhibitors such as RB-101 . ] However, in human models the data for antidepressant effects remains inconclusive.
- Panksepp is also well known for publishing a paper in 1979 suggesting that opioid peptides could play a role in the etiology of autism, which proposed that autism may be " an emotional disturbance arising from an upset in the opiate systems in the brain ".
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