quinolinic acid sentence in Hindi
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- Kynurenine 3-monooxygenase regulates the downstream production of quinolinic acid, which can generate reactive free radicals and activates the NMDA subtype of glutamate receptors, producing excitotoxic lesions in the central nervous system of mammals.
- Quinolinic acid activity has been associated with neurodegenerative disorders such as Huntington's disease, the neuroprective abilities of kynurenic acid forming a counterbalance against this process, and the related excitotoxicity and similar damaging effects on neurons.
- DPA-714, along with other members of the DPA class of TSPO ligands, has been shown to decrease microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration, suggesting potential neuroprotective effects.
- While astrocytes are not able to produce quinolinic acid directly, they are capable of producing KYNA, which when released from the astrocytes can be taken in by migroglia that can in turn increase quinolinic acid production.
- While astrocytes are not able to produce quinolinic acid directly, they are capable of producing KYNA, which when released from the astrocytes can be taken in by migroglia that can in turn increase quinolinic acid production.
- Under inflammatory conditions and conditions of T cell activation, leukocytes are retained in the brain by cytokine and chemokine production, which can lead to the breakdown of the BBB, thus increasing the quinolinic acid that enters the brain.
- Furthermore, quinolinic acid has been shown to play a role in destabilization of the cytoskeleton within astrocytes and brain endothelial cells, contributing to the degradation of the BBB, which results in higher concentrations of quinolinic acid in the brain.
- Furthermore, quinolinic acid has been shown to play a role in destabilization of the cytoskeleton within astrocytes and brain endothelial cells, contributing to the degradation of the BBB, which results in higher concentrations of quinolinic acid in the brain.
- In fact, the amount of quinolinic acid found in the brain of HAND patients can be up to 300 times greater than that found in the CSF . Neurons exposed to quinolinic acid for long periods of time can develop cortex.
- In fact, the amount of quinolinic acid found in the brain of HAND patients can be up to 300 times greater than that found in the CSF . Neurons exposed to quinolinic acid for long periods of time can develop cortex.
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