Splenic infarction can be due to vasculitis or diffuse intravascular coagulation.
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Splenic infarction can also result from a sickle cell crisis in patients with sickle cell anemia.
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Splenic infarction is also more common in hematological disorders with associated splenomegaly, such as the myeloproliferative disorders.
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In sickle cell disease, repeated splenic infarctions lead to a non-functional spleen ( autosplenectomy ).
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Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot.
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Abdominal pain due to hypersplenism and splenic infarction and right-upper quadrant pain caused by gallstones are major clinical manifestations.
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It turned out that Clark had suffered a splenic infarction due to the sickle cell trait from which he has suffered since he was a child; these are usually a risk at high altitudes.
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"' Splenic infarction "'is a condition in which oxygen supply to the spleen is interrupted, leading to partial or complete infarction ( tissue death due to oxygen shortage ) in the organ.
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Various other conditions have been associated with splenic infarction in case reporters, for example granulomatosis with polyangiitis or treatment with drugs that predispose to vasospasm or thrombosis, like vasoconstrictors used to treat esophageal varices, sumatriptan or bevacizumab.
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