1. Complications from argininosuccinic aciduria may include developmental delay and mental retardation. 2. Laboratory studies showed 3-hydroxyisobutyric aciduria and mild lactic acidosis. 3. Defective UMP synthase can result in orotic aciduria , a metabolic disorder. 4. -- Glutaric aciduria , or GA-1. 5. A UMP synthetase deficiency can result in a metabolic disorder called orotic aciduria . 6. Mutations in this gene have been shown to cause metaphyseal chondromatosis with aciduria . 7. Fewer than 20 cases of 3-methylglutaconic aciduria type I have been reported. 8. They also cause D-2-hydroxyglutaric aciduria and Ollier and Maffucci syndromes. 9. One mutation in patients with argininosuccinic aciduria occurs when glutamine 286 is mutated to arginine. 10. 3-Methylglutaconic aciduria , seems to be most prevalent amongst the Jewish population of Iraq.
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