Actinomycin is a complex molecule that intercalates DNA and prevents RNA synthesis.
The systematic name of this enzyme class is "'actinomycin lactonohydrolase " '.
Actinomycin-D is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis.
Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D ( 7-AAD ), are used as stains in microscopy and flow cytometry applications.
Animal studies have shown actinomycin-D is corrosive to skin, irritating to the eyes and mucous membranes of the respiratory tract and highly toxic by the oral route.
He is known for the discovery of actinomycin, and the development of the industrial production by fermentation of many natural products, including cyanocobalamin, the avermectins, and other important antibiotics.
It was at Rutgers that Waksman's team discovered several antibiotics, including actinomycin, clavacin, streptothricin, streptomycin, grisein, neomycin, fradicin, candicidin, candidin, and others.
Viral RdRPs were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA-directed RNA synthesis.
Through the sequential use of two drugs, methotrexate and actinomycin-D, cures were achieved in up to 90 percent of women with choriocarcinoma who were treated by 1972; 90 percent of those who were not treated died within a year.
""'Streptomyces flavovirens " "'is a bacterium species from the genus of " Streptomyces " which has been isolated from soil . " Streptomyces flavovirens " produces the actinomycin complex and mureidomycin.