1. "And alendronate is more effective, " he added. 2. Siris said alendronate works by coating surplus osteoclasts and suppressing their action. 3. This compound became known as Alendronate or Fosamax. 4. Earlier studies indicated alendronate reduced the incidence of " silent " spinal fractures. 5. For this reason, other bisphosphonates, like alendronate , are preferred when fighting osteoporosis. 6. Use of alendronate has been studied to prevent TRs and decrease progression of existing lesions. 7. Alendronate belongs to a class of drugs called bisphosphonates, which prevent bone from breaking down.8. Alendronate is administered in pill form.9. These include calcitonin, through a nasal spray or injections, and alendronate , an oral drug. 10. Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment.