arsphenamine sentence in Hindi
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- This substance, first called " 606 ", is now known as Arsphenamine or Salvarsan.
- Before sulfa came into use there was Arsphenamine } Salvarsan, used starting around 1910 to treat syphilis.
- With this new knowledge, Ehrlich tested Compound 606 ( chemically arsphenamine ) on a syphilis-infected rabbit.
- Arsphenamine, as well as neosalvarsan, was indicated for syphilis and trypanosomiasis, but has been superseded by modern antibiotics.
- Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity.
- His laboratory discovered arsphenamine ( Salvarsan ), the first effective medicinal treatment for syphilis, thereby initiating and also naming the concept of chemotherapy.
- When the study started, arsphenamine ( Salvarsan ) and Neosalvarsan were the only available treatments for syphilis, and both compounds had dangerous side effects.
- The first antibiotic was arsphenamine ( Salvarsan ) discovered by Paul Ehrlich in 1908 after he observed that bacteria took up toxic dyes that human cells did not.
- In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin.
- Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci.
- With the support of his assistant Sahachiro Hata Ehrlich discovered in 1909 that Compound 606, Arsphenamine effectively combatted " spirillum " spirochaetes bacteria, one of whose subspecies causes syphilis.
- Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.
- During the 18th, 19th, and 20th centuries, a number of arsenic compounds were used as medicines, including arsphenamine ( by Paul Ehrlich ) and arsenic trioxide ( by Thomas Fowler ).
- By 1910 Paul Ehrlich and his laboratory group began developing arsenic-based arsphenamine, ( Salvarsan ), as the first effective medicinal treatment of syphilis, and thereby initiated the medical practice of chemotherapy.
- The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata in the laboratory of Paul Ehrlich, is not toxic to bacteria until it has been converted to an active form by the body.
- Toxic metal compounds were used a lot, arsenic in the form of Fowler's solution, arsphenamine, or arsenic trioxide; thallium salts, various forms of mercury, like mercury ( II ) chloride.
- While in Germany, he took the opportunity to learn about chemotherapy at the German National Institute for Experimental Therapeutics in Frankfurt, where he assisted Paul Ehrlich in the discovery of arsphenamine, which proved effective in curing syphilis.
- Arsphenamine was originally called " 606 " because it was the sixth in the sixth group of compounds synthesized for testing; it was marketed by Hoechst AG under the trade name "'Salvarsan "'in 1910.
- Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against microorganism involved in syphilis, a disease roughly equivalent then to today's AIDS . In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for trypanosomiasis.
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