HRT can cause infertility, eventually leading to chemically induced aspermatogenesis.
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Aspermatogenesis in these mutant rats is due to a failure of homologous chromosome synapsis during meiosis.
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The first clinical features may appear in early childhood or, more frequently, during puberty, such as lack of secondary sexual characteristics and aspermatogenesis, while tall stature as a symptom can be hard to diagnose during puberty.
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