1. Mechanical injury to cartilage explants in culture also reduced autophagy proteins. 2. This data supports the development of therapies that will encourage autophagy . 3. Induced autophagy interfers with the action of the chemotherapy drug vincristine. 4. Knockdown of the PSMB7 gene may also induce autophagy in cardiomyocytes. 5. This inhibits autophagy , the major degradation pathway in eukaryotic cells. 6. Autophagy allows the orderly degradation and recycling of cellular components.7. The first Keystone Symposia on autophagy was held in 2007 at Monterey. 8. In both cases, autophagy is observed to markedly increase. 9. Moreover, active mTOR supports tumor growth also indirectly by inhibiting autophagy . 10. Sorafenib treatment induces autophagy , which may suppress tumor growth.
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