chemoresistance sentence in Hindi
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- MTDH has a dual role in promoting metastatic seeding and enhancing chemoresistance.
- The encoded protein may play a role in breast cancer proliferation and chemoresistance.
- In epithelial ovarian cancer, CLU has been observed to promote angiogenesis and chemoresistance.
- Notably, it has been associated with chemoresistance and, thus, is a promising therapeutic target for cancer treatment.
- MK has been identified as one of the factors that transfers this chemoresistance from the resistant cells to the WT cells.
- As evident by its key roles in cancer development, CLU can serve as a therapeutic target for fighting tumor growth and chemoresistance.
- Although gemcitabine has widely used to treat solid tumors for over a decade, patients taking gemcitabine alone ( monotherapy ) have been observed to develop chemoresistance to the drug.
- Finally recent studies showed that TEAD1 and YAP in ovarian cancer can induces cell stemness and chemoresistance . and that genetic variant of TEAD protein and YAP are enriched in some cancers.
- Along with its main oncogene function in hepatocellular carcinoma ( HCC ) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition ( EMT ), allergic response, inflammation and Alzheimer's disease.
- At the same time, high levels of DUT-N have been associated with chemoresistance and faster tumor progression, and thus, could also serve as a prognostic marker for overall survival and response to chemotherapy.
- Since it is known to be associated with metastasis and malignant transformation, Bmi-1 makes for a good marker of cancer and may hold prognostic or diagnostic value . and it is known for its association with chemoresistance to common chemotherapeutics.
- In colorectal cancer, ABCB5 was shown to act as a mediator of 5-FU patient chemoresistance, and had a further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts.
- This indicates that MK caused the cells to initiate the survival pathway ( via PKB, mTOR, and Bad activation ) and inhibit the senescent or apoptotic pathway ( via inhibiting caspase-3 ) encouraging the chemoresistance seen in resistant cells and in the co-culture experiments.
- Hyperthermia has also been shown to help prevent or reverse " chemo-resistance . " Chemotherapy resistance sometimes develops over time as the tumors adapt and can overcome the toxicity of the chemo medication . " Overcoming chemoresistance has been extensively studied within the past, especially using CDDP-resistant cells.
- In regard to the potential benefit that drug-resistant cells can be recruited for effective therapy by combining chemotherapy with hyperthermia, it was important to show that chemoresistance against several anticancer drugs ( e . g . mitomycin C, anthracyclines, BCNU, melphalan ) including CDDP could be reversed at least partially by the addition of heat.
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