1. Currently in the process of FDA approval is the injection of collagenase . 2. Collagenase " clostridium histolyticum " injection for Dupuytren's contracture.3. The treatment with collagenase is different for the MCP joint and the PIP joint. 4. The collagenase is distributed across three injection points. 5. This leads to local inflammation through the signalling of synovial cells to produce metalloproteinases and collagenase 6. Collagenase is only used when the ECM scaffold product does not require an intact collagen structure.7. At the same time, the cells begin making too little collagenase , the enzyme that destroys excess collagen. 8. Analysis of the primary structure of the gene sequence may thus be implicated in self-processing of the collagenase . 9. Collagenase solution is injected into the pancreatic duct which runs through the head, body and tail of the pancreas.10. This powder can then be mixed with collagenase to form an ECM derived hydrogel ( self-healing hydrogels ).
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