During the Great Disaster, Grant released the experimental animals affected by the drug, and dumped the Cortexin itself into the stream created by a broken water main.
2.
Shortly before the Great Disaster, a scientist at Walter Reed Army Medical Center, Dr . Michael Grant, developed a drug called Cortexin, which stimulated the reasoning abilities of animals.
3.
By Kamandi's time, an unspecified period after the Great Disaster, the effects of Cortexin and the radiation unleashed by the Great Disaster itself had caused a wide variety of animals ( most of them are descendants of escaped zoo animals following the disaster ) including but not limited to barracudas, bats, cheetahs, coyotes, crocodiles, dogs, gophers, gorillas, kangaroos, leopards, lions, lizards, wolves, to become bipedal, humanoid, and sentient, possessing the power of speech.
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