1. Mechanism of the classical Nazarov cyclization activated by Lewis acid catalyst. 2. It is formed from cyclization of lycopene by lycopene cyclase epsilon. 3. A characteristic reaction of phenylpropanoic acid is its cyclization to indanones. 4. Raymond utilized this property to perform acid-catalyzed Nazarov cyclization . 5. Cyclization creates a new stereogenic center at the carbonyl-bearing carbon.6. Cyclization via electrophilic addition of the GGPP affords Iabdanyl cation.7. Additional oxidation and cyclization clerodane pyrophosphate concludes the biosynthesis of salvinorin A. 8. A classic example is the cyclization of geranyl pyrophosphate to form limonene. 9. One major problem in DPP-4 inhibitor stability is intramolecular cyclization . 10. Many of these compounds are capable of undergoing Bergman cyclization .
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