1. In cardiac muscle, desmin is present in ?B-crystallin. 2. The presence of desmin and myogenin can be detected using immunohistochemistry. 3. Desmin is a 53.5 kD protein composed of 470 amino acids.4. Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue.5. Activated satellite cells also begin expressing muscle-specific filament proteins such as desmin as they differentiate. 6. Desmin has been evaluated for role in assessing the depth of invasion of urothelial carcinoma in TURBT specimens.7. Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites.8. Later, a yeast two-hybrid method was used to demonstrate that syncoilin is a binding partner of desmin . 9. LAM cells stain positively for smooth muscle actin, vimentin, desmin , and, often, estrogen and progesterone receptors. 10. Desmin protein may also bind to the DAG complex, and regions of it are known to be involved in signaling.
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