1. Maleic anhydride is a dienophile in the Diels-Alder reaction. 2. Norbornadiene is also a useful dienophile in Diels-Alder reactions. 3. The HOMO of the dienophile reacts with the LUMO of the diene. 4. The most important consideration in choice of dienophile is its relative orbital energies. 5. Imines are electron-poor, and thus usually function as the dienophile . 6. The catalyst encapsulates the diene and dienophile , increasing the effective concentration of reactants. 7. As such, the highly strained trans-cyclooctene is used as a reactive dienophile . 8. It is an excellent prochiral dienophile . 9. What type of substitution pattern would it encourage if I say, used pyrrole as the dienophile ? 10. However, when the dienophile substituents are endo, there is considerable orbital overlap with the diene.
Mobile