1. In contrast XX gonadal dysgenesis has a normal female chromosome situation. 2. Congenital hypothyroidism caused by thyroid dysgenesis can be associated with PAX8. 3. The P element gives rise to a phenotype known as hybrid dysgenesis . 4. Women with 46 XX gonadal dysgenesis experience primary amenorrhea with hypergonadotropic hypogonadism. 5. Mutations in the FOXE3 gene are associated with anterior segment mesenchymal dysgenesis . 6. The term dysgenesis is used to describe abnormal organ development during embryonic growth and development. 7. Although similar in some ways to mixed gonadal dysgenesis , the conditions can be distinguished histologically. 8. Microcornea and iridocorneal dysgenesis also occur. 9. In the rabbit model, disorders observed involving NR4A1 expression include testicular dysgenesis , and cryptorchidism. 10. Other disorders that result from STRA6 mutations include pulmonary dysgenesis , cardiac malformations, and mental retardation.
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