Cells remaining in the follicle then develop into the corpus luteum . ( b ) In this electron micrograph of a secondary follicle, the oocyte, theca cells ( thecae folliculi ), and developing antrum are clearly visible.
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During the reproductive years, most estradiol in women is produced by the granulosa cells of the ovaries by the aromatization of ? 4-androstenedione ( produced in the theca folliculi cells ) to estrone, followed by conversion of estrone to estradiol by 17?-hydroxysteroid dehydrogenase.
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