1. Gelatinase B may play an important role in angiogenesis and neovascularization.2. This enzyme is similar to gelatinase A, but possesses a further domain. 3. Caseinolytic and gelatinase activities are normally present. 4. Slough, southeast England-based Celltech has patented a number of inhibitors of human gelatinase . 5. Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence. 6. For example, gelatinase B appears to be involved in the remodeling associated with malignant glioma neovascularization. 7. When interacting with TGF-?, Gelatinase B also stimulates collagen contraction, aiding in wound closure. 8. Gelatinase B has been found to be associated with numerous pathological processes, including immunologic and vascular diseases.9. Elevated gelatinase B levels can also be found in the cases of rheumatoid arthritis and focal brain ischemia. 10. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family.
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