The dangers of exposure to mercury were reported during the nineteenth century when hat-makers were found developing peculiar symptoms of quiver and slurring of speech which gave rise to the phrase ' mad as a hatter ' . पारे के प्रभाव के खतरे के संबंध में उन्नीसवीं शताब्दी में सबसे पहले उस समय पता चला जब हैट बनाने वालों में आवाज की कंपकंपाहट तथा अस्पष्ट उच्चारण जैसे अजीब लक्षण दिखाई दिए .
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