Hydrastinine was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield.
2.
Hydrolysis of hydrastine yields hydrastinine, which was patented by Bayer as a haemostatic drug during the 1910s.
3.
"' Hydrastine "'is an alkaloid which was discovered in 1851 by Alfred P . Durand.
4.
In one study, the lethal dose ( LD 50 ) for rats was 12 times lower with hydrastine than with goldenseal extract.
5.
Research into the toxicology and pharmacology of goldenseal has focused on berberine and hydrastine, which are antimicrobial, chloretic and each have a variety of other properties helping immunity.
6.
"' Hydrastinine "'is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, which was found naturally in small quantities in " Hydrastis canadensis"
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