1. Diltiazem has negative inotropic , chronotropic, and dromotropic effects. 2. Neurotransmitters receptors can either be inotropic or g protein coupled. 3. Hypoxia, acidosis, hyperkalemia are also negative inotropic agents. 4. Negatively inotropic agents weaken the force of muscular contractions. 5. Positively inotropic agents increase the strength of muscular contraction. 6. Its inotropic and chronotropic effects elevate diastolic blood pressure. 7. Inotropic receptors allow for ions to pass through when agonized by a ligand.8. Agents that are dromotropic are often ( but not always ) inotropic and chronotropic. 9. Endothelin receptor activation mediates strong pulmonary vasoconstriction and positive inotropic effect on the heart. 10. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility.
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