1. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein . 2. HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin. 3. The inhibitor also inactivates kallikrein and plasmin, also involved in blood coagulation. 4. He named it kallikrein , by derivation from the Greek word for pancreas. 5. It inhibits proteases like chymotrypsin, kallikrein , plasmin, thrombin, and trypsin. 6. HMWK is essential for blood coagulation and assembly of the kallikrein -kinin system. 7. HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein . 8. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein . 9. KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. 10. ACh also causes the salivary gland to release kallikrein , an enzyme that converts kininogen to lysyl-bradykinin.
Mobile