In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy.
2.
This and other " Ammi " species are sources of khellin, a diuretic extract.
3.
Khellin has been used to relieve the pain associated with angina pectoris by acting as a selective coronary vasodilator.
4.
Khellin has also been used to treat renal colic, which is due mostly to schistosomiasis infections and stone formation.
5.
The plant is found to contain the furocoumarin isopimpenellin and five biogenetically related furocoumarins viz khellin, visnagin, visamminol, ammiol and khellol.
6.
Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative.
7.
"' Khellin "'has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including : renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis.
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