1. Modifications of lanosterol into other steroids are classified as steroidogenesis transformations. 2. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis.3. In humans, lanosterol synthase is encoded by the LSS gene. 4. Finally, lanosterol is converted to cholesterol through a 19-step process. 5. Lanosterol can then be converted into other steroids such as cholesterol and ergosterol.6. Because terbinafine prevents conversion of squalene to lanosterol , ergosterol cannot be synthesized. 7. Oxidosqualene cyclase then cyclizes squalene to form lanosterol . 8. Lanosterol can then be converted into other steroids, such as cholesterol and ergosterol.9. Incorporation of lanosterol into viridin has been described. 10. Lanosterol synthase inhibitors are thought to lower LDL and VLDL cholesterol by a dual control mechanism.
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