There are four known enzymes ( lanthipeptide synthetases ) responsible for producing lanthionine rings.
2.
Additional sources of lanthionine ketimine have been proposed.
3.
The name lantibiotics was introduced in 1988 as an abbreviation for " lanthionine-containing peptide antibiotics ".
4.
Lanthipeptides are characterized by the presence lanthionine ( Lan ) and 3-methyllanthionine ( MeLan ) residues.
5.
Lanthionine ketimine interacts with CRMP2 in affinity proteomics experiments and alters CRMP2 binding to other proteins in brain lysate preparations.
6.
Derivatives of lanthionine ketimine have been patented as experimental therapeutics to treat neurological diseases and diseases possessing a pathological inflammatory component.
7.
For example, some microbes make 2-aminoisobutyric acid and lanthionine, which is a sulfide-bridged derivative of alanine.
8.
In 1941, lanthionine was first isolated from the treatment of wool with sodium carbonate and was first synthesized from cysteine and ?-chloroalanine.
9.
Lanthionine ketimine also binds the brain protein lanthionine synthase-like protein-1 ( LANCL1 ), a glutathione-binding protein of uncertain function.
10.
Lanthionine ketimine also binds the brain protein lanthionine synthase-like protein-1 ( LANCL1 ), a glutathione-binding protein of uncertain function.
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